NKGen Biotech Inc. (NASDAQ: NKGN) shares fade slightly Tuesday. The Santa Ana, Calif.-based clinical-stage biotechnology company focused on the development and commercialization of innovative autologous and allogeneic natural killer cell therapeutics, today announced the presentation of two posters, on its first-in-kind, autologous, non-genetically modified NK cell product, troculeucel, in Alzheimer’s Disease (“AD”).
The posters entitled, “Use of Non-genetically Modified Natural Killer Cells (SNK01) With Enhanced Activity in Subjects with Active Alzheimer’s Disease. Further Biomarker Analysis and Implications for Use in Prevention” and “Treatment of Moderate Alzheimer’s Disease Subjects with Expanded Non-genetically Modified Natural Killer Cells (troculeucel; SNK01) with Enhanced Activity – Report of the Phase 1 results of the Phase 1/2a Study” were presented at the 17th Clinical Trials on Alzheimer’s Disease Annual Meeting on Tuesday.
NKGen previously showed, in a dose-escalation Phase 1 pilot trial, that four treatments with suboptimal doses of troculeucel in AD subjects were well-tolerated and had preliminary ability to impact cognition and improve protein and neuroinflammation biomarkers. Based on recent publications by Guo et. al., and Johansson et. al., which both reported the detection of several biomarkers a full decade before patients developed clinical symptoms of dementia, NKGen reanalyzed its biobank to determine if troculeucel effected specific biomarkers (e.g., GFAP, NfL, p-tau181, GDF-15, and LTBP2) implicated with increased AD risk.
NKGN shares lost 0.25 cents to 35 cents.
