Issued on behalf of Avaí Bio, Inc.
VANCOUVER — Baystreet.ca — Most people have never heard of α-Klotho. But the scientific community has been quietly obsessed with it since 1997, when Japanese researcher Makoto Kuro-O discovered that mice without the Klotho gene aged rapidly and died young — while mice with extra copies lived up to 30% longer.
In the decades since, the evidence has only gotten stronger. Studies from the Mayo Clinic link declining Klotho to arterial stiffness, endothelial dysfunction, and vascular calcification. Peer-reviewed research connects higher Klotho levels to reduced risk of Alzheimer’s, cardiovascular disease, and certain cancers. The protein modulates aging across the brain, heart, kidneys, and immune system simultaneously.
And your body cuts production by approximately 50% after age 40.
This biological reality is colliding with a market that’s accelerating toward it. The cell and gene therapy sector is forecast to reach $45 billion by 2035. Cell therapy alone surpassed $8.2 billion this year. CAR T-cell therapy is valued at nearly $7 billion, expanding at an 18% CAGR. But every one of these therapies — from gene editing to immune cell engineering — starts in the same place: with a single characterized cell that has been cloned and banked under conditions rigorous enough to support everything that comes after.
That cellular foundation is what separates promising science from actual development programs. Caribou Biosciences (NASDAQ: CRBU) is developing next-generation allogeneic CAR-T therapies using its proprietary chRDNA genome-editing platform, designed to create off-the-shelf cell treatments that eliminate the bottleneck of patient-specific manufacturing. Editas Medicine (NASDAQ: EDIT) is advancing in vivo gene editing therapies using CRISPR technology, with clinical programs targeting genetic eye diseases where a single treatment could replace a lifetime of management. Organogenesis (NASDAQ: ORGO) generates over $400 million in annual revenue from advanced wound care and surgical biologics, demonstrating that regenerative medicine can reach commercial scale. Inhibrx Biosciences (NASDAQ: INBX) is developing bispecific antibody-based therapies designed to redirect the immune system with greater precision than conventional approaches.
Each of these companies represents a piece of the regenerative medicine puzzle. But none of them is addressing what may be the most fundamental biological target in aging science: the age-related collapse of a protein that protects virtually every major organ system. And none of them started their programs without first establishing the cellular foundation to build on.
Avaí Bio (OTCQB: AVAI) recently announced it has begun creating a Master Cell Bank (MCB) of genetically modified cells that overexpress the α-Klotho protein, working alongside joint venture partner Austrianova through their shared entity, Klothonova. An MCB is the process of taking a single genetically engineered cell and cloning it into tens of millions of identical copies under GMP-compliant conditions — establishing the standardized, quality-controlled cellular starting material from which all future working cell banks and therapy development will proceed. It’s not the therapy itself. It’s the essential first step that makes developing the therapy possible.
“We are excited to enter the first step in the production phase of α-Klotho producing cells as part of our commitment to deliver safe, effective treatments for aging associated diseases,” said Chris Winter, CEO of Avaí Bio.
The cells banked in the MCB will be used with Austrianova’s proprietary Cell-in-a-Box® encapsulation technology, which protects cells inside a biocompatible shell to enable continuous protein secretion without immune rejection. The technology is backed by over 50 peer-reviewed publications. Avaí Bio’s dual-program approach also targets diabetes through the Insulinova platform, following participation at the 15th European Pancreas and Islet Transplantation Association Symposium in January 2026, where Dr. Eva Maria Lilli Brandtner evaluated advanced cells for potential application in insulin-producing cell therapies.
Your body is losing the protein that protects you from Alzheimer’s, heart disease, cancer, and kidney failure. The science to potentially address that loss exists. And Avaí Bio (OTCQB: AVAI) is currently establishing the cellular foundation required to advance that science — in a market where the cell and gene therapy sector is heading toward $45 billion and every company with a credible development program starts from exactly this step.
For more information on Avaí Bio (OTCQB: AVAI) and its Klothonova and Insulinova programs, visit Baystreet.ca
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SOURCES:
1. Straits Research, Global Cell Therapy Market 2026 — https://straitsresearch.com/report/cell-therapy-market
2. Precedence Research, Cell and Gene Therapy Market Forecast — https://www.precedenceresearch.com/cell-and-gene-therapy-market
3. Grand View Research, CAR T-Cell Therapy Market — https://www.grandviewresearch.com/industry-analysis/car-t-cell-therapy-market-report
4. Astute Analytica, Regenerative Medicine Market 2025–2033 — https://www.globenewswire.com/news-release/2026/01/27/3226653/0/en/Regenerative-Medicine-Market-Review-2020-2024-and-Forecast-2025-2033-A-578-29-Bn-Opportunity-Says-Astute-Analytica.html
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